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10.1016/j.neulet.2006.10.062 84 NassiniR.GeesM.HarrisonS.De SienaG.MaterazziS.MorettoN.et al

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This novel gene-nutrient interaction with implications for blood pressure management is important in public health terms, given that the frequency of the variant MTHFR 677TT genotype is 1012 % in the UK and Ireland but it varies according to the geographical area with the highest frequency of 3244 % is reported in Mexico (Reference Wilcken, Bamforth and Li115Reference Reyes, Godfrey and Ming117)