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Most researchers report first noticing skin texture improvements around week six to eight

Studies showed that Sermorelin treatment in adults with GHD could increase IGF-1 levels, though not always to the same extent as GH replacement, and produce improvements in body composition (increased lean mass, reduced fat mass), energy levels, exercise capacity, and quality of life measures

However, these effects were completely blunted in NaCl-restricted subjects, despite GH-stimulated renal ammonia production as suggested by increases in urine pH, and could be restored after changing back to a normal NaCL diet

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