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It has been hypothesized that IGF-1 LR3 may support neuronal survival and synaptic plasticity through its interaction with IGF-1R in the central nervous system

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Frequently Asked Questions 1Retatrutide Phase 2 Trial Triple Hormone Receptor Agonist for Obesity New England Journal of Medicine, 2023 2Bacteriostatic Water for Injection, USP Prescribing Information FDA, 2023 3Lilly TRIUMPH-1/2/3 Phase 3 Retatrutide Trial Registry ClinicalTrials.gov, 2024 Related Articles Retatrutide Retatrutide FDA Approval Timeline 2026: Latest Updates on the Triple Agonist Comparison Retatrutide vs Tirzepatide: Triple vs Dual Agonist Comparison Retatrutide Retatrutide Dosing Protocol & Titration Schedule: 1mg to 12mg Weekly Guide (2026) Tirzepatide How to Reconstitute Tirzepatide: Complete Mixing Guide (2026) Guide

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R-Lipoic acid impairs PDK binding and phosphorylation efficiency toward PDHC [185], whereas its analog CPI-613 disrupts mitochondrial metabolism by targeting PDHC and -ketoglutarate dehydrogenase/2-oxoglutarate dehydrogenase (OGDH), achieving tumor-selective cytotoxicity [186, 187]

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10.3389/fendo.2016.00030 96 ChoiI

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