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Nanoparticles in combating neuronal dysregulated signaling pathways: recent approaches to the nanoformulations of phytochemicals and synthetic drugs against neurodegenerative diseases

Causes and Risk Factors Smoking and tobacco smoke, which are implicated in approximately 85% of all lung cancers 5080% increased risk of lung cancer if first-degree relative or sibling has the disease Emphysema increases risk 2.44-fold and chronic bronchitis 1.47-fold Exposure to asbestos, diesel engine exhaust, air pollution, pesticides, and heavy metals are associated with lung cancer development Note: Recent evidence suggests e-cigarettes can harm the lungs

Further exploration of other in vivo tumor models as well as clinical studies is necessary to determine whether the limited dependence of some tumor cells on glutamine anaplerosis is associated with select oncogenic contexts or tissues of origin, or whether it reflects glutamine availability in the specific tissue environments

These mechanisms are crucial for the potential therapeutic effects of IF in neurodegenerative diseases (e.g., Alzheimers and Parkinsons disease), autoimmune diseases, and neurotraumatic conditions