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Furthermore, transglutaminase 2 can lead to neuronal death during stroke by inducing GSH depletion, thereby promoting ROS accumulation and ferroptosis (65)

As elucidated in this review, the GBA and ENS are fundamental drivers of CNS homeostasis and brain plasticity and are therefore fundamental inputs to the development and maintenance of higher-level processes of consciousness, not only for healthy individuals but especially for those on the spectrum or with other neurological challenges

de Cabo, R., & Mattson, M