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Nat Rev Rheumatol 10 , 561566 (2014)

Finally, we generated castration-resistant VCaP cells by switching regularly cultured VCaP cells (DMEM + 20% FBS) to CDSS-containing medium for 1 week followed by treatment with the PROTAC ARv7 degrader-1 (0.5 M, 24 h

The authors research whether TB-500 may tone down this signaling and suggest that the peptide may increase the level of miR-146a, a small regulatory RNA molecule whose role may be to act as an internal brake on inflammatory signaling pathways