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In another example of mRNA-based proinflammatory cytokine therapy, engineered IL-2 mRNA was loaded into polyethyleneimine-modified porous silica nanoparticles and delivered via intratumoral injection ( Figure 6B ) (121)

The enhanced dissolution behavior can be attributed to improved drug solubilization, reduced particle size, and formation of lipidsurfactant hybrid nanostructures, which collectively increase the effective surface area and improve wetting of SIL in aqueous media

Hendrayani SF, Al-Khalaf HH, Aboussekhra A

Exploring unconventional attributes of red blood cells and their potential applications in biomedicine