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182 Another phase II studies found that anlotinib monotherapy resulted in promising benefits as first- or second-line treatment in advanced HCC, 183 while the combination of chemotherapy did not provide additional efficacy

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Ethics approval and consent to participate The experimental procedures involving animals for the current study were carried out in accordance with the Chinese Guidelines for Animal Welfare and Experimental Protocol, and were approved by the Animal Care and Use Committee of Wuhan Polytechnic University