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Additionally, oxidative stress increases TYR activity and enhances melanosome transfer to keratinocytes, which further intensifies melanin synthesis and skin pigmentation 124,125

Alternative splice events Identification All the alternative splice events that occurred in our sample were identified by using the recently released program rMATS( Only the isoforms that were similar to the reference or comprised novel splice junctions were considered, and the splicing differences were detected as exon inclusion, exclusion, alternative 5, 3, and intron retention events

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