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Biddle, J

10.1016/j.cbi.2014.09.015 42 EmmaF.MontiniG.ParikhS

Wild-type mice express a single ApoE isoform that is structurally distinct from human ApoE isoforms, differing by approximately one-third of its nearly 300 amino acids and functionally resembling human ApoE3 rather than ApoE2 or ApoE4 [141]

Heavy metal contamination (e.g., lead, arsenic), microbial load, and pesticide residues should be evaluated according to pharmacopeial standards, especially for botanicals sourced from regions with lax environmental oversight