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[DOI] [PMC free article] [PubMed] [Google Scholar] 204.Nallathambi R., Mazuz M., Namdar D., Shik M., Namintzer D., Vinayaka A.C., Ion A., Faigenboim A., Nasser A., Laish I., et al

When its expression is disrupted, lactate cannot enter neurons normally, resulting in an insufficient neuronal energy supply

Because of similar pharmacological properties, it is reasonable to expect similar risk with the concomitant use of other CNS depressant drugs with opioid analgesics (see PRECAUTIONS, Drug Interactions)