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doi: 10.1038/s43018-024-00739-8 122 TassinariVJiaWChenW-LCandiEMelinoG

To this end, researchers have developed or screened a range of drugs and compounds capable of inhibiting ferroptosis through various approaches and have validated their neuroprotective effects using various disease models (Table III)

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Exploring the iron shuttle hypothesis in chelation therapy: effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture