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The construct was transiently transfected into HeLa cells together with increasing amounts of expression plasmids encoding GST, wild-type MxB, the short isoform of MxB (MxB 125), an MxB mutant where a specific residue that has been under strong positive selection in Old World monkeys and hominoids was converted to a residue found in New World monkeys (MxB G51Q) 21 , or an MxB mutant with a point mutation in the globular (G) domain that abrogates the GTP-hydrolysing activity (MxB T151A) 47,61

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PMID 28734939

The exact cause of the disease is still unknown (Reich et al., 2018), but it is characterized by neurodegeneration, inflammatory demyelination, primary demyelinating lesions, varying levels of axonal loss, and the proliferation of astrocytes and microglia (Reich et al., 2018