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These species are rich in cysteine and result in decreased drug availability and increased intracellular drug detoxification/inactivation, since platinum binds readily to sulfhydryl groups 29

In addition, the combination of Exos with antioxidants, iron chelators, or other therapeutic agents could boost their efficacy

Disrupting the clock in male mice via adipocyte-specific genetic deletion or high-fat-diet feeding reduces complex I respiration in adipocytes, leading to suppression of the peroxisome proliferator-activated receptor and insulin signalling pathways