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While human studies are ongoing, preclinical data highlight its role in reducing inflammation and promoting tissue regeneration

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Considering ROS and Ca 2+ are also core signaling modulators in various neutrophils responses, it remains an intriguing question how neutrophils prioritize downstream fates, such as phagocytosis, degranulation or releasing NETs, upon encountering the pathogens

12 Specifically, NAC is thought to affect thioredoxin expression, which regulates DNA binding of NF-kB and glutaredoxin expression that is responsible for detecting changes in the redox state of GSH