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ALC dose was 600 mg kg1 day1, based on the FDA allometric scaling factor of 0.081 ( FIGURE 1 2.3 mTBI modelling Mice in the rmTBI and ALC + rmTBI groups undertook 15 rmTBI across 23 days via an apparatus engineered to mimic the head acceleration forces of human mTBI, as described previously (Figure 2 provides the workflow of dosing, impacts, behaviour assessment and sample collection following final impact

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Activation of p53 signaling is Synergistically enhanced by Bcl-2 inhibition through induction of Noxa and Bak/Bax Heterodimers resulting in apoptosis of AML stem cells

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