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This is supported by evidence that antibodies to TNF exist to some extent even in healthy subjects (3234) and in individuals with autoimmune disease (35), while a similar literature does not exist for antibodies to TL1A

Histological analysis revealed that anagen hair follicles in anti-VEGFtreated mice were thinner (Figure 5, c and d) with a more than 30% reduction in bulb diameters (Figure 5e), mainly due to reduced thickness of the follicular epithelium, associated with a significant, more than 40% decrease of perifollicular vascularization (Figure 5, f and g)