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Establishing that individuals carrying loss-of-function MC1R variants have reduced capacity to respond to endogenous -MSH or exogenous MC1R agonists

One common blood measure in ME/CFS studies are cytokines , a broad class of inflammation-related signaling molecules comprising interferon (IFN), tumor necrosis factors (TNF), chemokines, lymphokines, and, most commonly, interleukins (IL)

Immunohistochemical analysis using myosin VIIa staining revealed that AAV-SIRT1 significantly reduced the OHC loss along the cochlear spiral following noise exposure (Fig