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Transporter activity peaks during the circadian active phase (daytime in humans) and decreases during rest phases, inversely related to neuronal activity

We grouped participants into WNL, mild, moderate, or severe depression PROMIS depression symptom categories 75,76

ECs, pericytes, astrocytes, and neurons, among other cell types, collectively modulate cerebral blood flow (CBF) to cater to the high-energy demands of highly active brain regions [2, 3]

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