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Komatsu N, Takayanagi H

When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders

The unusual spermidine-glutathione adduct named trypanothione or N1,N8-bis(glutathionyl)spermidine found solely in these parasites functions as an electron donor in many pathways by neutralizing diverse reactive species through redox reactions, also providing reducing equivalents to intermediate molecules in other antioxidant pathways and in biosynthetic pathways such as DNA synthesis [35, 36]

The cognitive difference was significant sustained focus through 8-hour days, less mental fatigue, better pattern recognition