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The primary routes for permeation across the BBBinclude passive diffusion (lipid soluble solutes), ABC transporter efflux, carrier-mediated influx, and receptor-mediated transcytosis (Abbott et al., 2010)

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Nowadays we can understand that sex, age, race and ethnicity, in the context of socioeconomic status and lifestyle (tobacco, alcohol, education, physical exercise, unbalanced diet, etc.) impacts directly in its prevalence [7, 8, 10, 27 36]

A review article from 2012 summarized the findings for different hormonal birth control options, and found that certain anti-HIV drugs can make the pill less effective at preventing pregnancy [7]