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From the paper titled " The basis for folinic acid treatment in neuro-psychiatric disorders " by Ramaekers et al., 2016: On the left side of the figure, the purine metabolite GTP serves as the substrate for the GTP-cyclohydrolase I enzyme (GTPCH) to produce tetrahydrobiopterin (BH4), which is the co- factor for enzymes producing dopamine, serotonin and NO