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It was also approved in combination with Merck's Keytruda (pembrolizumab) or Keytruda Qlex (pembrolizumab and berahyaluronidase alfa-pmph) for the first-line treatment of adults with unresectable locally advanced or metastatic TNBC whose tumors express PD-L1 (CPS 10) as determined by an FDA-authorized test

Second, the doses

The first indication of Reelin regulation by DNA methylation comes from the studies on patients with schizophrenia and psychotic bipolar disorder, in which lower mRNA levels of Reelin correlated with its promoter hypermethylation (Veldic et al., 2005)

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