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What is the level of risk for re-development of advanced periodontitis and likelihood of recurrence

The primary theoretical concern is that sustained NAD+ elevation through chronic NNMT inhibition could activate pathways (PARP, SIRT1) that have context-dependent roles in cancer biology NAD+ supports DNA repair and cellular longevity, but also fuels rapidly dividing cells

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Russo MV, Latour LL, McGavern DB (2018) Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury