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Specifically, State 3 respiration, which is critical for ATP generation, was significantly impaired in the diabetic groups, while baseline (State 4) respiration remained unchanged

[DOI] [PMC free article] [PubMed] [Google Scholar] 135.McLeod F., Salinas P.C

Elevation of ROS levels induced by GSTP-silencing Since antioxidant activity is one of the essential functions of the GST superfamily, GSTP-silencing is expected to be a ROS inducer that leads to oxidative stress with excessive ROS accumulation