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The interface features a hydrophobic patch involving three tryptophan residues, two from the DARPin and one from p53, and two salt-bridge networks via p53 residues Arg110 and Asp148

In this study, the mice were pretreated with resveratrol 5 days before and 1 day after prior to a large single dose partial-body (abdominal) irradiation

Highlighting this protective role, in vivo astrocyte-specific disruption of autophagy exacerbates hallmark AD pathologies, including greater plaque burden, increased tau phosphorylation, reactive astrogliosis, neuronal loss, and cognitive impairments, while astrocytic LC3B overexpression ameliorates these phenotypes [135]

By removing the PTEN gene from the oocytes of mouse primordial follicles, it is possible that the formation of primordial follicles and the early activation of the entire primordial follicle pool during puberty would be facilitated