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10.3389/FPHAR.2022.922232 200 YagishitaY.FaheyJ

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Stabilized HIF-1 translocate to the nucleus, where it dimerizes with HIF-1 and drives the transcription of genes that promote glycolytic metabolism, including glucose transporters and key glycolytic enzymes such as GLUT1 and lactate dehydrogenase A (LDHA), thereby reinforcing a metabolic shift toward aerobic glycolysis (9496)