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Seven approaches were studied, including exercise, hydrotherapy, acupuncture, low-level laser therapy (LLLT), electromagnetic therapy, TENS, whole-body vibration (WBV), and exergaming

To further support the transcriptomic findings, we examined the expression of several representative proteins associated with the implicated pathways

A visual analogue scale of pain (VAS) consisting of a 10 cm long horizontal line marked "absence of pain" at one end (0) and "worst possible pain" at the other end (10)

Evidence from animal and cell-based models points toward potential interactions in muscle, bone, cartilage, cardiac, and neural tissues