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While this might seem ideal for therapeutic efficacy, it overwhelms the liver's detoxification pathways

CBS mRNA induction has been shown to occur in response to the transcription factor Nrf2 [14], in response to several hormones including 1,25-dihydroxyvitamin D3 (the biologically active form of vitamin D) [15], various estrogen receptor ligands [16] and glucocorticoids [17]