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Conclusion: This study revealed a critical role of CRL3 in hepatic metabolic regulation and identified NRF2-mediated NADH-reductive stress as a previously unrecognized downstream effector modulating the development of hepatic steatosis

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LAT2 ( SLC7A8 ), another important BCAA transporter, has been reported to be abnormally expressed in cancers (Wang and Holst, 2015)

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