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tb inside the granulomas from T2DM subjects ( Figure 2A )

Also, after recognizing pathogens, certain cells (mainly lung macrophages and DCs) act as antigen-presenting cells (APCs), and they present the major histocompatibility complex class I (MCH I) and activating antigen-specific T cells (CD4 + T cells and CD8 + T cells) for the specific clearance of the antigen, thus preventing the replication and spread of the pathogen [70, 71]