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Monitor patients closely, and perform serum liver testing prior to therapy and at frequent intervals thereafter (5.1) Fetal Risk, particularly neural tube defects, other major malformations, and decreased IQ (5.2, 5.3, 5.4) Pancreatitis, including fatal hemorrhagic cases (5.5) Recent Major Changes Indications and Usage for Depakote Depakote is an anti-epileptic drug indicated for: Treatment of manic episodes associated with bipolar disorder (1.1) Monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures

It is involved in the signaling for survival and transcription through associations with the Egr-1 transcription factor and Akt/PI3K cell survival pathway

Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle

If double-strand breaks are not properly repaired or are misrepaired, they can result in chromosomal instability, cell death, and the incidence of cancer (Chiorcea-Paquim 2022)