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Functional roles of E6 and E7 oncoproteins in HPV-induced malignancies at diverse anatomical sites

Using synergistic drug combination prediction algorithms, such as multi-objective evolutionary algorithms and random search algorithms, synergistic drug combinations can be rapidly screened from large-scale drug combination spaces (Zinner et al., 2009)

347,348,357 This concept aligns with findings from a mouse model study, which showed a decrease in the mtDNA deletion load with age in affected tissues, such as peripheral blood and liver