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Distinct variabilities of infection rates, epidemiological transmission, and clinical outcomes during COVID-19 pandemic raises an intriguing question, whether the emergence of SARS-CoV-2 variants of concern (VOCs) with function-specific mutations in ACE2, furin, and TMPRSS2 expression has played any role in disease manifestations and case fatality rates (CFR) 55,75

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Patients had an Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1, or 2, as well as measurable disease by the Response Evaluation Criteria in Solid Tumors (RECIST version 1.1) 51 , and could either nave for any previous systemic treatment or have had any number of prior systemic therapies