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In a colorectal cancer (CRC) lung metastasis model, gut dysbiosis-induced TCA accumulation promoted M-MDSC expansion and immunosuppressive function by enhancing glycolysis and epigenetically stabilizing PD-L1 expression via H3K4 mono-methylation, with potential involvement of the Farnesoid X Receptor (FXR) ( Conversely, targeting BA metabolism offers a promising strategy to reduce MDSC-mediated immunosuppression

Hairy cell leukaemia, a rare indolent lymphoproliferative disorder, may occasionally be associated with monocytopenia, although other abnormalities (especially neutropenia and lymphocytosis) would generally be present

Dietary quality amplifies drug effects: GLP-1 receptor agonists reduce appetite and caloric intake, but the nutritional quality of consumed calories still matters for health outcomes

Methylcobalamin tends to be dosed at the same intervals as cyanocobalamin but may allow some patients to stretch the time between injections once their tissue stores stabilize