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Seek immediate medical attention if you experience: Sudden vision loss or significant vision reduction in one or both eyes Sudden painless severe vision loss (possible central retinal artery occlusion) Floaters, flashes of light, or a curtain-like shadow across your visual field (possible retinal detachment) Eye pain, redness, or discharge accompanying vision changes Double vision or new onset of seeing halos around lights Vision changes accompanied by severe headache, confusion, or neurological symptoms These symptoms may indicate serious conditions such as retinal detachment, acute angle-closure glaucoma, diabetic macular edema, or other emergencies requiring urgent ophthalmologic evaluation

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In further embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with one or more cations chosen from 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, 2aa, 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, and 2aa