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(63) demonstrated that the DIO2 Thr92Ala polymorphism substantially reduces type 2 deiodinase activity, impairs local T4-to-T3 conversion, and is associated with lower serum T3 levels in patients treated with levothyroxine

It's not a diagnosis in itself but rather a symptom of an underlying problem

notably, its ability to utilize methemoglobin and bacterial hemoproteins as a heme source provides a competitive advantage over resident gut microbes ( Bacteroides fragilis proteins like BfrA, potentially disrupting microbial mutualism in the gut and exacerbating dysbiosis ( P.g exhibits a pronounced tropism for the intestinal mucosa, demonstrating a higher adhesive capacity to intestinal epithelial cells compared to other oral bacteria like Prevotella intermedia , an action primarily mediated by its gingipain proteases ( The ectopic colonization of P.g acts as a primary instigator of profound gut microbiota dysbiosis

As an antioxidant, Glutathione is capable of stopping damage to essential cellular components produced by reactive oxygen varieties like free radicals, peroxides, lipid peroxides, and abundant metals