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In CP and PG, all values were below the limit of detection (Table 2)

10.1016/j.toxlet.2016.07.001 Toxicol

Haji et al., 2022)

We also discuss the reasons for the poor efficacy of opioids, given the commonness of opioid tolerance caused by NP and/or repeated opioid treatments, an angle that has received little attention to date