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In this study, we attempted to generate C57BL/6 mice deficient in both Adh5 and Aldh2 , which encode two major enzymes that metabolize endogenous formaldehyde, in order to understand the effects of endogenous formaldehyde on mice with normal DNA repair function

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Protein oxidation Exposure of proteins to ROS results in multiple changes, including amino acid residues oxidation, protein fragmentation due to oxidative cleavage of the peptide backbone, irreversible production of protein carbonyl compounds and generation of proteinprotein cross-linkages [33,34,35,36]