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Second, some clinical studies have potential limitations due to the limited number of cancer patients participating in the study and the lack of long-term follow-up of measured outcomes

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Some animal model studies have established no difference in atherosclerotic lesion size between specific pathogen-free (conventionally raised, CONV-R) and germ-free (GF) mice on a high-fat diet (HFD) (14, 18), while others have noted bigger atherosclerotic lesion sizes in GF mice than in CONV-R mice on chow (18, 19)

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