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Therefore, investigations designed to elucidate differential glycosylation and sialylation properties of ApoE isoforms within specific tissue or cell types will be essential for gaining insights into the localized roles of these PTMs on ApoE-related physiology and pathophysiology

Therefore, ROS levels in tumors and lymphocytes may be potential indicators of responsiveness to PD-1/PD-L1 blockade therapy, especially considering that the expression of immune checkpoints has been recognized as an intrinsic marker of tumor vulnerability to ICI therapy [236]