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OSTEOPONTIN (OPN)

Administration of N-acetylcysteine (the safer of the two) within 816 hours following acetaminophen overdosage has been shown to protect victims from fulminant hepatotoxicity and death (see Chapter 59: Management of the Poisoned Patient)

Additionally, NETs facilitate the activation of CD4 + T cells and the phagocytic function of macrophages through inflammasome signaling

Because FA cannot bind fibrinogen until it is cleaved by thrombin activated at the injury site we anticipated that this region could act as a 'safety lock', minimising potential non-specific fibrinogen aggregation