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Eligible participants held a medical license to practice in Switzerland, had multiple years of experience managing pain with opioid analgesics, and represented different medical specialties

Claudin-5 is Downregulated by TGF 1 in bEnd.3 Cells As TGF 1 was shown to increase permeability of bEnd.3 monolayers and induce an upregulation of MMP9, further investigation into tight junction protein regulation was warranted

The level of statistical significance was set at 0.05