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Proc Natl Acad Sci 102(43):1554515550

This peptide is the active ingredient in the topical copper peptides that have been sold as cosmetic agents on the dermatology shelf since the late 1980s, with the caveat being that topical GHK-Cu needs to penetrate the stratum corneum layer of skin before getting to the dermis, which houses the receptors for the peptide

2 Materials and methods 2.1 Construction of a nonalcoholic fatty liver model Male C57 mice aged 8 weeks and weighing between 18 and 22 g were randomly allocated into two groups: 9 mice in the high-fat group and 8 in the control group

Both rates of non-enzymatic and enzymatic reaction of GSH with MBB were observed to increase with the increasing value of pH (6.0-8.0) of the buffer solution