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CoV-Y is also tightly packed, but pAE indicates a clear divide between Y1 and CoV-Y at Gly1763 (see Fig 7B)

Its performance characteristics include: Glutathione coupled to Sepharose High Performance, excellent for high resolution purification of GST-tagged proteins Easy one-step purification of GST-tagged proteins and other glutathione S-transferase or glutathionedependent proteins Prepacked GSTrap HP columns for simple operation with a syringe, pump or chromatographic system, such as KTAdesign These features make Glutathione Sepharose High Performance the ideal medium for high resolution purification of GST-tagged proteins, glutathione S-transferases and glutathione binding proteins

On the other hand, it must be stressed that the above values are averages and there might be significant spatial heterogeneity 57

In 2011, dimeric integrin targeting PDCs were designed (Kimura et al., 2011), which featured ortho -carboranes as center and two cyclic c(RGDfK) peptides that were separately conjugated via a butanoic acid linker to each carbon atom in the cluster (Figure 10A)