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Because it is difficult to heat solids to temperatures above their melting points, and because pure solids tend to melt over a very small temperature range, melting points are often used to help identify compounds

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However, such studies have demonstrated that NAC and S-CMC reduced the exacerbation risk only in patients not treated with ICS, whereas erdosteine reduced COPD exacerbations irrespective of concomitant ICS use suggesting that erdosteine has additional pharmacological actions to ICS