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Indeed we could only detect significant levels of the specific DHA-derived lipoperoxide 4-hydroxy-2-hexenal (HHE) after 36 h exposure to DHA, just before upregulation of Gpx4 expression occurred

Nevertheless, the fact that these animals are immunosuppressed, a condition needed to allow tumor engraftment excluding the rejection in adult mice, represents a restraint in their use as immunotherapies testing (126)