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In APP/PS1 mice (APPswe/PSEN1dE9 transgenic mice model of AD), transcriptome analysis identified the enriched ACSL4 (Yan et al., 2022), which can be inhibited by tetrahydroxy stilbene glycoside (TSG) (Peng et al., 2021)

Darrieutort-Laffite et al., 2024)

The researchers concluded that AOD9604 displayed a very good safety and tolerability profile indistinguishable from placebo. Critically, zero serious adverse events were attributed to the peptide, and no participants withdrew due to treatment-related effects

Importantly, the 9-me-BC-treated rats were otherwise healthy, meaning that the results of the study can be extrapolated to potential nootropic efficacy in healthy humans, rather than, as is often the case, surmising potential effects based off of studies normally performed in either animal models of cognitive disorder, or in humans with reduced mental function