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The RI/ proteins were accumulated in large, discrete puncta in Akap11 -deficient neurons, as shown through immunofluorescence (IF) imaging (Fig

Common causes include: Poor dietary intake (common in vegans and vegetarians) Malabsorption disorders (e.g., pernicious anemia, celiac disease, Crohns disease) Certain medications (e.g., metformin, proton pump inhibitors) Aging (reduced stomach acid affects absorption) Alcoholism (impairs absorption) Gastrointestinal surgery (such as gastric bypass or removal of part of the stomach) What is the fastest way to fix B12 deficiency

However, understanding when high B12 levels may become problematic helps ensure safe, evidence-based supplementation under appropriate medical supervision