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These findings support previous research indicating quercetin uses oxidative stress to activate the Nrf2 signaling pathway, which is determined by ERK and AKT [70]

Additionally, the upregulated genes relevent to iron homeostasis also include gene ecoding ferritin light chain (FTL) protein, the gene encoding microtubule-associated proteins 1 A/1B light chain 3B (MAP1LC3B) and the gene encoding nuclear receptor coactivator (NCOA4)

This leaves practitioners in a difficult position: acknowledging a promising safety signal while recognizing the profound limitations of unpublished data

In the future, the focus of CRC treatment will gradually shift from a driver gene-based approach to a metabolic ecosystem-based approach